三氯乙烯致作业人群抑癌基因启动子区甲基化的研究
基本信息
结项摘要
大量的流行病学调查显示，三氯乙烯（TCE）长期接触可致肾癌发病危险度增加。抑癌基因启动子区甲基化被认为是肿瘤发生发展中的重要生物学事件。本研究采用横断面设计，在职业人群中开展TCE致DNA甲基化标志物的研究，通过进行系统的TCE暴露评价、分析重要的抑癌基因启动子区甲基化状态，探讨职业TCE暴露能否引起重要抑癌基因启动子区甲基化，阐明该职业人群甲基化抑癌基因谱的构成及其与TCE暴露的剂量-反应关系。并从DNA损伤修复能力、基因遗传变异及参与甲基转移与供给的营养因子水平三个方面探讨该表遗传调控模式改变的影响因素及作用特点。为TCE致癌机理探索、寻找敏感特异的致癌生物标志物提供科学依据。
项目摘要
项目成果
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数据更新时间：2023-05-31
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