损失规避支配假说的提出与验证

Decision making under uncertainty is a fundamental human behavior. The underlying neurocognitive mechanisms of decision making have been recognized as an important question in scientific research, and the corresponding findings has been applied to the fields of politics, economics and individual mental health. By employing the functional magnetic resonance imaging (fMRI) together with the recently developed stereo-electroencephalography (SEEG) and computational modeling, the overall goal of our proposed project is to identify the core brain circuits and oscillations underlying the avoidance motivation in decision making, especially two key neural circuits: the “amygdala - orbital prefrontal cortex (OFC) ”circuit and the “ventral striatum - OFC ”circuit, and to establish a loss-aversion dominance hypothesis of decision making under uncertainty. We expect that the findings of the proposed projects will provide scientific evidence to enhance individual ability to cope with decisions under uncertainty, as well as the intervention and treatment of decision-making deficits in mental disorders. The proposed research is expected to have at least one landmark achievements with international reputation, and more than four top level publications in high-profile journals. The principal investigator and the team members have published 88 journal articles (SCI) in recent 5 years, including high-profile journals like Brain, The Journal of Neuroscience, NeuroImage and Human Brain Mapping. The collaboration platform equipped with large-scale neuroscienctific equipment will also guarantee the success of this project.

不确定性条件下的决策是人类的基本行为之一，其认知与神经机制的研究已成为当前多学科交叉的重大前沿科学问题，涉及到政治、经济、生活与个体心理健康等领域。本项目将通过整合最新的脑功能成像、立体定位脑电图、计算建模等技术，在全脑功能连接、神经回路振荡、直至行为等多个层面上，揭示不确定性决策中以损失规避为主导的规避动机与行为的认知机制与神经基础，重点考查“伏隔核—腹内侧前额叶”与“杏仁核—腹内侧前额叶”等关键神经环路上的响应与通信机制，进而建立损失规避主导下的不确定性决策模型，提出损失规避支配假设。从而为提高个体风险决策能力以及干预和治疗决策相关临床障碍提供重要的科学依据。本项目拟完成1项有国际显示度的标志性成果，发表4篇以上有国际影响力的高水平论文。项目申请人团队在近5年发表SCI论文88篇，项目依托单位与合作单位已装备必要的仪器设备并搭建完善的科研平台，为项目开展与实施提供有力保证。

不确定性条件下的决策是人类的基本行为之一，其认知与神经机制的研究已成为当前多学科交叉的重大前沿科学问题，涉及到政治、经济、生活与个体心理健康等领域。本项目通过整合脑电、脑功能成像、计算建模等技术，在全脑功能连接、神经振荡、直至行为等多个层面上，探讨了不确定性决策中以损失规避为主导的规避动机与行为的认知机制与神经基础。本项目发现损失规避在个体的风险决策和社会决策的决策偏好中占主导作用，主要与杏仁核-前额叶通路、突显网络-颞顶联合区等脑网络连接有关，并且建立了基于脑网络连接的个体社会行为决策预测模型，为提高个体风险决策能力以及干预和治疗决策相关临床障碍提供了重要的科学依据。通过本项目的实施，项目团队发表SCI/SSCI论文28篇，JCR 1区论文20篇、影响因子10分以上4篇，申请国家发明专利1项，授权国家发明专利2项，获软件著作权3项，省部级自然科学二等奖1项，获批国家级项目1项，联合培养博士生2名、硕士生8名，组织国际学术研讨会1次，参加6次以上国内外大型学术会议并作报告，引起了国内外同行的广泛关注，具有一定的国际影响力。