基于多肽生物传感的促癌氧化应激微环境分析

The development of many tumors can arise from chronic oxidative stress, and most anti-cancer therapies also induce elevated level of oxidative stress. However, a definite relationship between oxidative stress and cancer pathology has not been established. So this project is planned to develop a bioanalytical strategy to delineate the role of oxidative stress in promoting/inhibiting cancer, by studying the direct effect of oxidative stress in the pro-cancerous microenvironment. The designed strategy employs peptide-based biosensing probes and molecular scaffold to analyze multiple components of the microenvironment, directly in the context of their interactions. The application of this method may deepen the current understanding of oxidative stress-associated development of cancer, and may also facilitate the therapeutic efforts of developing novel anti-cancer therapy.

病灶局部长期氧化应激是癌症的重要诱因之一，且各类癌症治疗手段多会造成肿瘤组织氧化应激水平的提高。然而，氧化应激水平与癌症病理之间的关系目前仍然存在许多矛盾和争议。因此本项目计划利用多肽设计分子探针及分子支架，对氧化应激微环境各个要素进行直接和综合的分析，建立氧化应激微环境的直接分析技术，以研究氧化应激对于促癌微环境各组分的直接效应，并通过分析临床病理样本，结合现有的相关研究进展，明确氧化应激的癌症病理作用，以深化目前对于促癌病理机制的认知，推动癌症的抗氧化治疗等新型治疗方案的发展。

病灶局部长期氧化应激是癌症的重要诱因之一，且各类癌症治疗手段多会造成肿瘤组织氧化应激水平的提高。然而，氧化应激水平与癌症病理之间的关系目前仍然存在许多矛盾和争议。因此本项目计划利用多肽设计分子探针及分子支架，对氧化应激微环境各个要素进行直接和综合的分析，建立氧化应激微环境的直接分析技术，以研究氧化应激对于促癌微环境各组分的直接效应，并通过分析临床病理样本，结合现有的相关研究进展，明确氧化应激的癌症病理作用，以深化目前对于促癌病理机制的认知，推动癌症的抗氧化治疗等新型治疗方案的发展。