RTK调制钾通道GIRK的分子与结构基础
基本信息
结项摘要
本项目拟结合运用膜片箝记录、区段突变体扫描、定点突变、重组蛋白结合与磷酸化检测等技术，在原有工作基础上，深入研究酪氨酸激酶型受体EGFR、Trk、Ret等不同成员激活后对GIRK的调制作用，分析酪氨酸激酶型受体调制GIRK的特异性；确定酪氨酸激酶型受体调制GIRK的位点并明确其结构特点；分析GIRK的酪氨酸激酶型受体调制位点与已发现的G蛋白bg亚基、PIP2位点的关系；从而深入阐明酪氨酸激酶型受体调制钾通道GIRK的分子与结构基础。本研究对于认识酪氨酸激酶型受体在调制神经元兴奋性中的作用以及生长因子的调质样效应机制具有重要意义。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Protective effect of Schisandra chinensis lignans on hypoxia-induced PC12 cells and signal transduction
Protective effect of Schisandra chinensis lignans on hypoxia-induced PC12 cells and signal transduction
MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body
MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body
Mechanical vibration mitigates the decrease of bone quantity and bone quality of leptin receptor-deficient db/db mice by promoting bone formation and inhibiting bone resorption.
Mechanical vibration mitigates the decrease of bone quantity and bone quality of leptin receptor-deficient db/db mice by promoting bone formation and inhibiting bone resorption.
One-step prepared prussian blue/porous carbon composite derives highly efficient Fe-N-C catalyst for oxygen reduction
One-step prepared prussian blue/porous carbon composite derives highly efficient Fe-N-C catalyst for oxygen reduction
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway
路长林的其他基金
相似国自然基金
Dok PTB结构域与RTK相互作用的分子和结构基础
ATP敏感性钾通道调制小胶质细胞活化的细胞与分子机制研究
不同钾通道SKCa孔区外庭功能多样的分子基础研究
GIRK4与肥胖相关的分子机制研究