基于舌象图像矢量模型的中医证候疗效评价支持方法研究

To establish objective effective "syndromes curative effect evaluation method" is the urgent demand of modern development of traditional Chinese medicine. Four diagnostic information and syndromes curative effect evaluation is the main basis of tongue diagnosis is an important part of four diagnosis. In recent years, with the development of tongue diagnosis informatization technology, based on the curative effect of tongue image analysis and evaluation support method has become possible. This study based on tongue diagnosis informatization technology, put forward a kind of normal tongue image index and centered, tongue image index change is to point to "tongue image vector model", the implementation of tongue image vector evaluation index changes. Study intends to establish normal tongue image index "benchmark parameters", and is an object with chronic spleen and stomach disease, cardiovascular disease, to qi deficiency, blood deficiency, Yin deficiency, Yang deficiency, and qi stagnation, blood stasis and phlegmy wet, cold, heat and other 9 kinds of common basis of TCM syndrome before and after treatment of tongue image index and trend analysis, a clear change and curative effect of tongue image correlation, establish "tongue - efficacy concentration-response relationship" evaluation function, establish a "normal" tongue as benchmark parameters and vector change direction, "image" to evaluate the curative effect evaluation based on vector model, and combining the model and the clinical curative effect evaluation method, based on the syndrome of traditional Chinese medicine efficacy of tongue image analysis and evaluation support method.

建立客观有效的"中医证候疗效评价方法"是中医现代发展的迫切需求。四诊信息是证候诊断和疗效评价的主要依据，舌诊是四诊重要内容。近年来随着舌诊信息化技术的发展，建立基于舌象图像分析的疗效评价支持方法已经成为可能。本研究在舌象信息化诊断技术基础上，提出了一种以正常舌象图像指标为中心、证候舌象图像指标变化为指向的"舌象图像矢量模型"，实现对舌象图像指标变化的矢量评价。研究拟建立正常舌象图像指标的"基准参数"，并以慢性脾胃病、心血管疾病为对象，对气虚、血虚、阴虚、阳虚、气滞、血瘀、痰湿、实寒、实热等9种中医常见基础证候治疗前后的舌象图像指标变化趋势进行分析，明确舌象图像变化与疗效的相关性，确立"舌象-疗效量效关系"评价函数，建立以"正常舌象基准参数"和"图像矢量变化方向、程度"为评价依据的疗效评价矢量模型，并将该模型与临床疗效评价方法相结合，建立基于舌象图像分析的中医证候疗效评价支持方法。

建立客观有效的“中医证候疗效评价方法”是中医现代发展的迫切需求。四诊信息是证候诊断和疗效评价的主要依据，舌诊是四诊重要内容。近年来随着舌诊信息化技术的发展，建立基于舌象图像分析的疗效评价支持方法已经成为可能。本研究通过标准化条件采集健康体检人群舌象图像1788例，建立了基于专家共识的舌象标准图库，选取基础单证和舌象敏感指标，建立了正常舌象图像指标的参数基准范围，并以慢性脾胃病、心血管疾病等内科疾病为对象，采集疾病人群（包括糖尿病、甲状腺疾病、脾胃病、肿瘤等内科疾病）舌象图像894 例，对气血虚证、寒证、热证、血瘀证、痰湿证、气滞证等中医常见基础证候治疗前后的舌象图像指标变化趋势进行分析，建立以“正常舌象基准参数”和“图像矢量变化方向、程度”为评价依据的疗效评价矢量模型，并将该模型与临床疗效评价方法相结合，确立了“舌象疗效量-效关系”评价函数，建立基于舌象图像分析的中医证候疗效评价支持方法。本研究还探索性建立了基于分区差值局部特征的舌象动态监测与评价方法。 . 本研究共发表论文18篇，其中SCI收录8篇，出版专著1部，获得发明专利1项，申报软件著作权2项，获得授权1项，获得中国中西医结合学会技术二等奖1项，浦东新区科学技术奖三等奖1项，培养硕士研究生3人，博士研究生7人。