异种器官移植超急性排斥反应中α1,3GT基因的机理研究
基本信息
结项摘要
猪血管内皮细胞表面的α1，3半乳糖是被人天然抗体识别引发超急性排斥反应的主要位点，α1，3半乳糖转移α1，3GT是该位点形成的关键酶。本项目拟用基因打靶技术，使猪血管内皮细胞α1，3GT编码基因失活，剔除细胞表面的α1，3半乳糖位点，同时转入人CD55和CD59基因，使猪血管内皮细胞表达人的CD55和CD59，检测该细胞株对人免疫成分的抵抗程度。.
项目摘要
项目成果
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数据更新时间：2023-05-31
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