反义RNA抑制异种移植排斥反应的实验研究
基本信息
结项摘要
建立猪主动脉内皮细胞株，确定α1，3半乳糖基转移酶基因的调控序列及转录起始点，用反义寡脱氧核糖核酸确定最佳抑制点，构建反义表达逆转录病毒载体，转入猪主动脉内皮细胞，检测α1，3半乳糖表位的表达情况及对人血清的耐受力。本研究有助于明确异种移植中的排斥反应机制，拓宽反义技术的应用领域。
项目摘要
项目成果
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数据更新时间：2023-05-31
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