转T-bet和c-FLIP cDNA的肿瘤特异性T细胞抗肝癌及机制的实验研究
基本信息
结项摘要
一、克隆T-bet cDNA和c-FLIP cDNA，构建其双价真核表达载体pEGFP/T-bet-IRES-c-FLIP；二、从肝癌患者外周血分离树突状细胞（DC）和T细胞，然后用吞噬了凋亡肝癌细胞的DC与T细胞混合培养，利用DC吞噬凋亡细胞后强大的交叉呈递能力，刺激肿瘤特异性CD4Th细胞和CD8Tc细胞扩增；三、用pEGFP/T-bet-IRES-c-FLIP转染上述扩增后的T细胞，通过T
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数据更新时间：2023-05-31
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