茶多酚多功能协同材料的构建及用于修复慢性伤口

Chronic wounds have caused serious health problems and enormous financial burdens worldwide and for treating chronic wounds, it is crucial to find adequate solutions to its complicated wound environments. In this project, a kind of multifunctional biomaterials based on the salient features of green tea polyphenols are fabricated, with all-in-one properties integrated with controlled ROS, metallic release and material degradation, to address this scientific problem associated with chronic wound healing. The biomaterials combine the excellent properties of both tea polyphenols and natural macromolecules through covalent assembly, and tea polyphenols are employed to precisely modulate the ROS levels to match the requirements at different stages of wound healing. Meanwhile, the metal ions are introduced and their release from the biomaterials is thus controlled, thanks to the formation of polyphenol-metal coordination. In addition, the degradation of biomaterials could be easily tailored by cross-linking degree among tea polyphenols and natural biomacromolecules with agents. The physicochemical properties of these multifunctional biomaterials will be optimized, and then their biological performances including cell experiments and the wound healing with animal models of chronic wounds are further investigated. It is expected that through the successful implementation of this project, a novel solution to treat chronic wounds will be provided on the basis of utilizing green tea polyphenols. Therefore, it is of great scientific significance to carry out this project which would also yield achievements with promising applications.

慢性伤口在世界范围内都带来了非常严重的健康问题和经济负担，治疗慢性伤口解决其复杂的伤口环境是关键。针对这一关键科学问题，本项目提出利用天然可食用的茶多酚自身分子结构具有的抗氧化、配位金属离子和具有多个反应位点的特点，构建“ROS调控、金属离子缓释和降解可控”的多功能一体化材料治疗慢性伤口。该材料以茶多酚和天然大分子通过共价组装为主体，结合两者的优异性能；利用茶多酚精准控制材料对伤口ROS水平的影响，匹配组织各个修复阶段的ROS需求；通过茶多酚-金属配位结构引入金属离子，在多酚降解的过程中缓释金属离子；改变交联分子、调控反应程度构建可控降解度凝胶支架，获得慢性伤口修复的多功能协同材料。开展材料的各个体外基础生物学评价及在体内的修复效果实验。为天然资源的利用和慢性伤口的治疗提供新的思路，具有重大的科学意义和应用前景。

慢性伤口在世界范围内都带来了非常严重的健康问题和经济负担，治疗慢性伤口解决其复杂的伤口环境是关键。针对这一关键科学问题，本项目提出利用天然可食用的茶多酚自身分子结构具有的抗氧化、配位金属离子和具有多个反应位点的特点，构建“ROS调控、金属离子缓释和降解可控”的多功能一体化材料治疗慢性伤口。该材料以茶多酚和天然大分子通过共价组装为主体，结合两者的优异性能；利用茶多酚精准控制材料对伤口ROS水平的影响，匹配组织各个修复阶段的ROS需求；通过茶多酚-金属配位结构引入金属离子，在多酚降解的过程中缓释金属离子；改变交联分子、调控反应程度构建可控降解度凝胶支架，获得慢性伤口修复的多功能协同材料。开展材料的各个体外基础生物学评价及在体内的修复效果实验。为天然资源的利用和慢性伤口的治疗提供新的思路，具有重大的科学意义和应用前景。