HTPAP基因抑制肝癌转移的机制研究
基本信息
结项摘要
HTPAP基因是我们发现的抑制肝癌转移的基因。它在发生转移的HCC组织和细胞中的表达下降，并在体内体外试验都已证明该基因的表达具有抑制肿瘤细胞侵袭和转移的作用。关于HTPAP抑制肝癌转移的机制，迄今未见报道。. 本项目拟在现有工作的基础上，应用分子生物学相关技术Realtime-PCR、Western blot、荧光素酶双报告检测、电泳迁移率分析（EMSA）、免疫共沉淀（Co-IP）以及蛋白芯片等技术，构建HTPAP启动子调控模型，绘制HTPAP相关的蛋白作用网络图谱，明确HTPAP抑制肝癌转移的调控机制，为肝癌转移复发的分子预测和分子干预奠定基础。
项目摘要
项目成果
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数据更新时间：2023-05-31
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