引发式化学气相沉积法制备绿色抗菌食品包装镀膜

The foodborne pathogenic microorganisms often cause food poison and seriously endanger public health, therefore, it is important to control and prevent the damage of the foodborne pathogenic microorganisms to human health. With the rapid advancement of the food industry in our country, the antibacterial materials for food packaging have been gradually developing. By means of antifouling against bacterial adhesion or killing bacteria, the antibacterial materials can control the foodborne illness during food storage and transportation. In this project, we will use initiated chemical vapor deposition (iCVD) to modify the surface of the food packaging materials with polyampholytes, which will allow the surface to acquire the effective antifouling ability at mild conditions. Furthermore, we aim to develop a new type of antibacterial materials that combine the capacities of killing bacteria and antifouling against bacterial adhesion together. We will use the iCVD grafting method to graft polyampholyte onto the bactericidal polymers. In the present project, fourier transform infrared spectroscopy, contact angle goniometer, nuclear magnetic resonance, and atomic force microscopy will be employed to characterize the synthesized polymer films and further analyze the antibacterial mechanism of the films. Finally, the biocompatibility and stability of the films will be tested to ensure the safety and reliability of the antibacterial materials. On the whole, the purpose of our project is to apply the effective antibacterial films to the fabrication of antibacterial food packaging materials under the environment-friendly conditions of iCVD.

食源性致病微生物经常引起人们食物中毒且严重危害人体健康，是食品污染防治中需严格把关的环节。随着我国食品工业的快速发展，抗菌食品包装材料逐渐发展起来。通过抗细菌粘附或者直接杀菌的方式，抗菌材料能够控制病源微生物在食品贮藏和运输过程中对食品安全造成的危害。本项目拟通过绿色镀膜技术-引发式化学气相沉积（iCVD）将聚两性电解质镀覆在食品包装材料表面，使其获得高效抗细菌粘附的能力。此外，本项目拟研发集杀菌与抗细菌粘附为一体的新型抗菌材料，通过iCVD嫁接技术，将抗细菌粘附的聚两性电解质嫁接在杀菌高聚物镀膜表面。通过红外光谱、接触角、核磁共振、原子力显微镜等技术对材料进行表征；针对食源性致病菌，对薄膜的抗菌效率进行测试；结合材料特性及其抗菌效果，对材料抗菌机理进行系统研究；最后，通过生物相容性和材料稳定性的考察确保抗菌镀膜的安全性。总之，本项目拟通过绿色环保的iCVD技术制备安全的抗菌食品包装材料。

本项目围绕引发式化学气相沉积（ICVD）技术设计并合成了一系列具有抗菌和抗粘附的高分子涂层，主要研究结果如下：.1）通过iCVD技术合成具有抗细菌粘附性质的双层一体的聚两性电解质涂层P(DMAMS-co-MAA-co-EGDA)-g-P(DMAMS-co-MAA)和P(DMAEMA-co-MAA-co-EGDA)-g-P(DMAEMA-co-MAA)；.2）通过iCVD一步合成具有杀菌、pH响应性释放细菌残骸、良好生物相容性、且能循环使用的层级的高分子涂层P(DMAMS-co-EGDA)-g-P(VP-co-EGDA)；.3）通过iCVD一步法合成疏水正电防污杀菌的P(DMAMS-co-PFDA)高分子涂层；.4）通过iCVD制备碘（I）释放型抗菌的P(VP-co-EGDA)-I涂层。.5）发表论文16篇；撰写编著章节一章；授权1项国家发明专利，申请3项国家发明专利；参加会议交流。. 一些实验结果目前正在整理补充中，后续会以论文的形式发表提交。