基于网络药理学技术研究益气补血类中药调节成体干细胞和机体再生功能的作用机制

Traditional Chinese Medicines (TCMs) are great treasure in the biomedical area. Stem cell research is key for development of regenerative medicine. In addition, the theory of Qi and Blood in TCM is similar to the concept of stem cells in modern biology. However, there are few interdisciplinary studies across TCM and stem cell research. The function of TCM components in regulation of stem cell activity and tissue regeneration are lack of systematic research. In this study, information about components, docking targets, relative pathways and relative diseases of commonly used TCMs for tonifying Qi and enriching blood are collected. A four-dimensional network of TCM in regulating stem cell -related diseases will be set up through network pharmacology technique. Furthermore，the mechanism of TCMs in regulation of stem cell activity will be investigated in adult stem cells. This study could explore the mechanism of TCM components in improving stem cell activity and tissue regeneration, which provide innovative ideas and candidates for drug development. The results also have important theoretical significance for explaining the theory of TCM characteristics.

中药资源是生物医药领域的巨大宝库，干细胞研究对于再生医学的发展有重要意义，并且中医的气血理论与现代生物学中干细胞的理念有一定的相似性。但是目前中药和成体干细胞的交叉性研究还很少，缺乏中药活性成分调节成体干细胞和机体再生功能的系统性研究。本课题计划对常用的益气补血类中药材的成分、对接靶点、相关通路、相关疾病的信息进行收集，通过网络药理学技术建设个性化的调节干细胞活性的药材-成分-靶点-通路四维网络，并进一步采用成体干细胞模型研究益气补血类中药调节干细胞功能的活性和作用机制。该研究结果对于阐明中药活性成分在改善干细胞和机体再生功能方面的作用机制有重要意义，并且可以从干细胞角度解释传统中药材的药性理论，为治疗干细胞相关疾病的中药研发提供了创新的思路和候选药物。

中药资源是生物医药领域的巨大宝库，中医的气血理论与现代生物学中干细胞的理念有一定的关联性，因此中药活性成分和组织再生方向的交叉性研究具有重要的意义。本研究对常用的益气补血类中药材的成分、对接靶点、相关通路、相关疾病的信息进行收集，通过网络药理学技术建立了药材-成分-靶点-通路分子网络，采用细胞模型对益气补血类中药材中的活性成分在调节细胞功能和活性方面的作用进行了研究，并进一步在组织再生的动物模型领域进行探索。该研究结果为阐明中药活性成分在改善干细胞活性和调节机体再生功能方面的作用提供理论支持。