可控降解镁合金放射性碘-125粒子链研制及临床前研究

The effect of tumor treatments was induced caused by non-uniform distribution of radioactive iodine-125 in tumors which associated with doctor's surgical operation.We designed a controllable degradation radioactive seeds chain, which was composed of radioactive seeds and magnesium microtubules. It has confirmed that the radioactive seeds would be distributed evenly in tumors in our previous studies, due to the chain complete degradation in approximately 21 days after implantation.In this study, we will apply in vitro cytotoxicity test of the AZ31 magnesium tube, dose distribution of radioactive iodine-125 seeds chain by Monte Carlo simulated method and thermoluminescence dose measurement, and animal experiments of iodine-125 seeds chain implantation, to explore the cytotoxicity, biodegradablity and compatibility of magnesium alloy tube, and the radioactive dose distribution of iodine-125 seeds chain, in order to provide the basis for its preclinical application.We also want to develop a useful radioactive iodine-125 seeds chain with a reasonable structure design, aim to make it for clinical application. The characteristic of seeds chain as follows: 1.Distributed evenly in tumor, controllable interval, 2.Controllable degradation; 3.Well biocompatibility; 4.Convenient in clinical application. Compared to interstitial implantation of iodine-125 seeds, implantation of iodine-125 seeds chains reduces the amount of radioactive iodine-125 seeds; thereupon, it saves health care resources and improves therapeutic effect. It will be beneficial to the radiation protection of medical staff and patients also, due to the significant reduction of operation time.

放射性碘-125粒子在植入术中难以整齐均匀分布于肿瘤内，致肿瘤受辐射剂量不均，影响治疗效果。因此，我们设计了一种可控降解型放射性粒子链，通过镁合金微管将碘-125粒子连接成链状，而且在前期的动物实验研究中，已证实粒子链在植入后约第21天完全降解，粒子均匀分布于肿瘤内。本研究将通过体外AZ31镁管细胞毒性实验、放射性粒子链蒙地卡罗方法计算其理论剂量与通过热释光剂量计测量其实际剂量，以及粒子链动物植入实验，旨在探讨镁合金管细胞毒性、生物相容性、生物降解性以及粒子链放射性剂量分布等，为放射性粒子链临床应用做好基础研究。并通过合理的粒子链结构设计，以期研制出可供临床应用的放射性粒子链，其特点：1.使粒子均匀分布于肿瘤内，间距可控；2.可控降解；3.生物相容性好；4.使用方便、操作简单。减少放射性粒子的使用量，提高疗效，节约医疗资源，减少手术时间，也利于医护人员与患者的辐射防护。

放射性碘-125粒子在植入术中难以整齐均匀分布于肿瘤内，致肿瘤受辐射剂量不均，影响治疗效果。因此，我们设计了一种可控降解型放射性粒子链，通过镁合金微管将碘-125粒子连接成链状，而且在前期的动物实验研究中，已证实粒子链在植入后约第21天完全降解，粒子均匀分布于肿瘤内。本研究将通过体外AZ31镁管细胞毒性实验、放射性粒子链蒙地卡罗方法计算其理论剂量与通过热释光剂量计测量其实际剂量，以及粒子链动物植入实验，旨在探讨镁合金管细胞毒性、生物相容性、生物降解性以及粒子链放射性剂量分布等，为放射性粒子链临床应用做好基础研究。并通过合理的粒子链结构设计，以期研制出可供临床应用的放射性粒子链，其特点：1.使粒子均匀分布于肿瘤内，间距可控；2.可控降解；3.生物相容性好；4.使用方便、操作简单。减少放射性粒子的使用量，提高疗效，节约医疗资源，减少手术时间，也利于医护人员与患者的辐射防护。