以细菌外毒素B亚单位为载体的口服免疫耐受实验研究
基本信息
结项摘要
证明鼻粘膜免疫耐受可有效抑制实验性自身免疫性脑脊髓炎（EAE）的发生，耐受组动物E花环形成试验、淋巴细胞转化试验及迟发型超敏反应明显受到抑制，外周血淋巴细胞培养后测得IL-4水平明显升高，而IFN-γ水平则明显降低。表明鼻粘膜摄入小量自身抗原是诱导疾病免疫耐受的有效途径，并经病理学检查证实。鼻粘膜免疫耐受具有更有效、所需耐受原剂量更小的优点。耐受组豚鼠外周血IFN-γ水平明显低于非耐受组，而IL-4则明显高于非耐受组，提示其机制可能与Th1反应受抑制或促炎症性细胞因子如IFN-γ分泌下调及Th2反应增强或抗炎症性细胞因子如IL-4分泌上调有关。
项目摘要
项目成果
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数据更新时间：2023-05-31
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