基因组序列的理论分析

Empirical rules based on tetranucleotide parameters were presented to predict structural parameters, namely (Ω, ρ, τ and Dy). A statistical mechanical model was suggested to analyze the dynamic flexibility of the Escherichia coli genome. The terminus region of replication displayed a low level of flexibility. A strong correlation between G+C content and flexibility can be seen. Average flexibilities in coding regions were found to be significantly larger than those in non-coding regions. The flexible characteristics in three class sigma promoter sequences in the Escherichia coli genome were also analyzed.

通过对人类基因组序列的收集、比对、统计、加工，侧生探讨序列非编友区的信息结构与生物学功能，进行与基因组信息相关的核酸、蛋白质空间结构的预测以及蛋白质功能预测，研究分子进化和遗传密码起源的问题，开发新的研究工具和二级数据库。进而探索生命的起源、进化、遗传和发育的本质，破译隐藏在DNA序列中的遗传语言。.