MSC来源的exosome的分离鉴定及其抗肿瘤活性的机制研究
基本信息
结项摘要
exosome作为一种非常有效的肿瘤免疫治疗的非细胞疫苗已经成为肿瘤免疫治疗的新热点。exosome也是细胞间信息传递的一种重要途径。目前国内外均未见对MSC来源的exosome的研究报道。MSC来源丰富，在体外能够大量扩增，用IFN-γ处理后具有明显的抗原提呈功能，能够刺激肿瘤特异性免疫反应。本课题拟从MSC中分离鉴定exosome，并系统开展其生物学特性研究，加深对MSC生物学特征及相关功能的理解和认识；深入研究来源于IFN-γ处理后MSC的exosome的抗肿瘤活性，进一步探讨MSC抗肿瘤的生物学功能及作用机制，为exosome的临床应用提供实验依据。
项目摘要
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数据更新时间：2023-05-31
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