胰腺癌MUC4抗原多表位嵌合DNA疫苗的设计和免疫研究
基本信息
结项摘要
胰腺癌手术切除率低，化疗敏感性差，五年存活率<2%，迫切需要发展包括免疫治疗在内的新治疗手段。MUC4是新型的高敏、高特异的胰腺癌相关抗原，是较理想的胰腺癌肿瘤疫苗靶抗原；DNA疫苗是肿瘤疫苗发展新趋势；多表位嵌合的新型DNA疫苗技术能进一步解决DNA疫苗免疫原性低的难题；四聚体技术是DNA疫苗筛选验证的先进技术。本课题设计构建胰腺癌MUC4抗原多表位嵌合DNA疫苗；利用四聚体技术辅助DNA疫苗筛选验证，探索胰腺癌的肿瘤疫苗疗法。目前国内外无类似研究报道
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数据更新时间：2023-05-31
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