基于水杨酸残留高选择性吸附的分子印迹膜的制备及分离行为机理研究

Salicylic acid series products (SASP) is widely used in the field of medicine, food and beauty, the purity of the product is directly related to human life and health safety issues. therefore, it’s an urgent need to create a highly selective separation and purification technology of SASP, which was green, efficient, simple, to achieve tremendous economic and social value. In this project, the molecular imprinting technology and membrane separation technology will be coupled forming molecularly imprinted membrane technology, realizing the selective separation and edulcoration for SASP; a new molecularly imprinted membrane will be prepared by atom transfer radical polymerization techniques(ATRP), the imprinted layer of which possess uniform thickness and controllable molecular weight; another molecularly imprinted membrane will be synthetized by Surface molecularly imprinted layer-by-layer assembly technology to selective removal of some special charged impurities; advanced characterization methods will be employed to expound the physical and chemical properties of the synthetic molecular imprinted membrane, and explain imprinting polymerization and the kinetics, thermodynamic properties in the process of selective removal of impurities; study the separation mechanism of molecular imprinted membrane and establishing the corresponding kinetic,thermodynamic and hydrodynamic model.

水杨酸系列产品（SASP）广泛应用于医药、食品及美容领域，而产品的纯度直接关系到人类的生命健康和安全问题。因此，迫切需要建立一种绿色、高效、便捷的SASP高选择性分离纯化技术，实现更大的经济和社会价值。本课题拟将分子印迹技术和膜分离技术耦合制备分子印迹膜，并应用于水杨酸系列产品的选择性分离和除杂；结合原子转移自由基聚合技术，可控合成印迹层厚度均一、分子量可控的分子印迹膜；结合表面交替层状组装技术，合成对某些特殊带电荷杂质选择性去除的分子印迹膜；运用先进的表征手段，阐述合成的印迹膜的物理、化学特性，解释印迹聚合和选择性分离除杂过程中的平衡、动力学和热力学性质；研究分子印迹膜的分离机理，建立相应的动力学、热力学及流体力学模型。

水杨酸（Salicylic Acid，SA）是一种非常重要的有机合成原料，随着工业、医药及生活中SA的大量生产和使用，难以去除和分离的SA不断进入水体环境中。研究表明，人体长期接触SA会致使皮肤灼伤、眼损害、头晕、抽搐以及粘膜内出血等问题，因此急需寻求一种环境水体中高效分离SA的方法。本课题以多种聚合物有机膜为载体，制备合成了用于水杨酸选择性识别与分离的分子印迹复合膜；探讨了不同聚合方式（如：光引发聚合，微乳液聚合、可逆加成断裂链转移聚合等）制备得到的分子印迹膜材料对选择性分离行为的影响；通过引入离子液体实现了聚合物的绿色合成和可控合成的结合；探究了水呼吸模板法与分子印迹技术相结合制备有序多孔分子印迹膜的协同作用；通过对水杨酸类物质的选择性分离性能研究，获得水杨酸印迹复合膜结构与性能之间的构效关系。此外，实验中还分别通过半共价法和非共价法制备了的陶瓷印迹膜；基于相转化法制备了聚偏氟乙烯微孔印迹膜；基于相转化法，以离子液体为绿色合成溶剂制备了醋酸纤维素共混印迹膜。基于对上述膜材料选择性分离水杨酸类物质的研究，提高了项目成果的适用性。