惰性C-H键的高效转化及其应用

Direct C-H transformation under mild and enviromentally bengin condition is an ideal approach to construct C-C bonds, which is also the most competitive research field in chemistry. In the past two decades, significant progress has been made to approach the activation of C-H bonds of (hetero)arenes and aliphatic substrates. However, the challengings remained on the aspects of the narrow substarte scopes, limited reaction classes as well as the relatively coimplicated catalytic systems. Based on the previous studies in this field, this proposal focuses on the exploration of new methods to approach the selective common aryl C-H bonds and aliphatic C-H bonds owing to the understanding and tuning of the catatic pathways. The enantioselective C-H transformation is also a major point of this project. Other than C-C bond construction, we supposedly extend our proposed systems to build up the C-X (heteroatom) bonds, which are abundant in natural products and synthetic valuable chemicals. Another goal of this proposal is to imobolize the catalysts in the C-H tranformations to make the developed methods applicable in industry.

环境友好的，温和的C-H键活化反应将是构建C-C键的最理想手段，这也是目前和未来最有竞争力的化学研究领域之一。芳香烃和脂肪族C-H键的活化研究最近取得了可喜的进展, 但是无论从反应的底物，催化体系还是反应类型都具有很大的局限性。本项目就是结合目前研究现状和申请人的研究积累，设计并以期通过对反应机理的调控实现普通芳烃的C-H选择性活化，脂肪族C-H的区域选择性和立体选择性的化学转化；同时也希望发展全新的反应类型从烃类化合物出发构建新的碳杂原子键等，从而发展从C-H键出发直接合成具有潜在生理活性和应用价值的有机化合物的合成方法学，实现有限资源的合理利用。同时我们也希望通过对反应机理的进一步探索，积累对惰性C-H的本质及其反应性的认识，实现均相催化异相化，为化学工业的绿色化和可持续发展做贡献。

环境友好的，温和的C-H键活化反应将是构建C-C键的最理想手段，这也是目前和未来最有竞争力的化学研究领域之一。芳香烃和脂肪族C-H键的活化研究最近取得了可喜的进展, 但是无论从反应的底物，催化体系还是反应类型都具有很大的局限性。本项目就是结合目前研究现状和申请人的研究积累，设计并以期通过对反应机理的调控实现普通芳烃的C-H选择性活化，脂肪族C-H的区域选择性和立体选择性的化学转化；同时也希望发展全新的反应类型从烃类化合物出发构建新的碳杂原子键等，从而发展从C-H键出发直接合成具有潜在生理活性和应用价值的有机化合物的合成方法学，实现有限资源的合理利用。同时我们也希望通过对反应机理的进一步探索，积累对惰性C-H的本质及其反应性的认识，实现均相催化异相化，为化学工业的绿色化和可持续发展做贡献。