丹参和麦门冬促唾液分泌的机制及在义齿黏附剂中的缓释调控研究

There is 12～57% of population 50 years or older has dry mouth complaints. Dry mouth is becoming a severe problem affecting living quality of old people. The common used drugs----Pilocarpine and Cevimeline have serious adverse reaction. Actually, Chinese traditional medicine has excellent effective for dry mouth, such as DanShen and Maimendong. However, it is still not yet clear about the mechanism of promoting salivary secretion of both medicine, and it is difficult to maintain the effective drug concentration. The present study is investigate the promoting salivary secretion mechanism of Danshen and Maimendong, explicit the relationship of drug concentration and salivary secretion amount; the denture adhesive with sustained-releasing Danshen and Maimendong will be prepared based on the fact that old people often need restore with removable denture. The release kinetics of both drug and effect on the mechanical properties of denture adhesive will be examined. Finally, the excellent denture adhesive with sustained-releasing effective drug concentration will be developed. The result of this study will be provide a new way to treat dry mouth and increase denture comfort.

12%～57％的50岁以上人群有明显口腔干燥症状，成为严重影响老年人生活质量的重要问题，目前治疗多采用类胆碱或肾上腺素药物，但是副作用大且不能长期用药。传统中药在治疗口腔干燥方面具有较好的效果，副作用小，如丹参和麦门冬，但是其对唾液腺的作用机理还未阐明，而且在口腔内难以维持长久的有效浓度。本课题重点研究丹参和麦门冬刺激唾液分泌的作用机制，明确药物浓度与唾液分泌量的量效关系；根据中老年牙列缺损发病率高、常需佩戴可摘义齿的特点，拟设计制备可缓释丹参和麦门冬的义齿黏附剂，研究两种中药成分的缓释动力学过程，通过调整义齿黏附剂缓释微球的大小及添加量调控丹参和麦门冬的缓释速度，通过研究缓释微球对义齿黏附剂物理机械性能的影响，实现可稳定释放有效药物浓度且物理机械性能优良的义齿黏附剂。本课题的研究成果将为解除老年口腔干燥患者的症状、增加义齿舒适度、防止继发炎症、提高生活质量提供创新性解决方案。

本项目针对老年人群口腔干燥发病率高、口腔干燥综合征病人治疗手段有限等临床问题，拟打算采用义齿粘附剂作为载体，将安全性和生物相容性好的中药成分，比如丹参和麦门冬作为突进唾液分泌的药物，添加到义齿粘附剂中，起到药物缓释的作用，解决口腔干燥病人戴义齿困难的问题。本研究按计划制备了义齿粘附剂，制备的义齿粘附剂和同类市售产品相比，提高了义齿粘附剂的粘接强度和持久性； 研究了中药成分对唾液分泌的剂量效应关系；并研究了中药添加对义齿粘附剂物理机械性能的影响，在原计划基础上增加了茯苓和冬葵子中药对物理机械性能的影响；在原计划的基础上，还将丹参和黄芪用于了组织调整材中，起到了促血管生长的作用。本研究的结果为中药添加到口腔材料中提供了一定的参考意义和临床使用价值。