肝素类液晶化合物的合成及其在抗凝血材料中的应用

The proteins and most of carbohydrates are possess of the helical structure. Y. Xie et al. studied the liquid crystal theory of biomembranes and gave the first indication that biomembranes are in the liquid crystal state as a result of the amphiphilic molecules can form lyotropic liquid crystal in water. Heparin is a linear polysaccharide composed of repeating units of uronic acid, possessing many biological activities that include the ability to modulate embryonic development, tissue homeostasis, wound healing, and novel blood-compatibility. Heparin have been widely used as anticoagulant and adjuvant of blood-compatibility materials due to their excellent blood compatibility. It is common knowledge that there are many liquid crystals phenomena in biological system, such as sterone hormone, marrow phospholipid in neurotissue, mussel fiber, lipids in connective tissue and so on. So we assume that heparin liquid crystal may improve the blood compatibility if it is blended with polymer and the composite surface can be covered by liquid crystal state, then we can acquire excellent anti-coagulant biomaterials. In this study we have first synthesized a series of novel heparin liquid crystal in the world and the relationship between the heparin liquid crystal type and the hemocompatibility of liquid crystal materials.

在国际上首次模仿生物体内的液晶现象，以肝素分子为基体制备肝素类液晶化合物，并将其用于抗凝血材料的研究。在详细研究肝素类液晶的结构、形态、液晶现象以及抗血栓形成的基础上，利用低温等离子体技术将其接枝到高分子材料表面。重点研究材料表面的液晶性能对材料抗凝血性能的影响，克服肝素类高分子中肝素流失和活性下降这一国际上目前公认的难点。