RGD肽类和拟肽类血小板聚集抑制剂的合成与活性研究
基本信息
结项摘要
本课题（1）通过优化反应条件，制备出具有较低毒性的3.8nm级水平的超顺磁性氧化铁微粒（MION），X射线衍射分析证实主要成分为Fe304晶体，外层包被小分子量右旋糖酐，该微粒除可应用于单抗的标记外，今后尚有开发成新药制剂的潜在价值。（2）利用抗有肺癌单抗标记在MION上，成功地实现荷瘤裸鼠病灶的定向磁共振信号改变，认为随着标记技术提高和磁共振成像技术的发展，磁共振免疫成像可能是一种有发展前景的特异性肿瘤成像新方法。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
DNAgenie: accurate prediction of DNA-type-specific binding residues in protein sequences
DNAgenie: accurate prediction of DNA-type-specific binding residues in protein sequences
黄曲霉毒素B1检测与脱毒方法最新研究进展
黄曲霉毒素B1检测与脱毒方法最新研究进展
Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.
Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.
Interferon-based treatment is superior to nucleos(t)ide analog in reducing HBV-related hepatocellular carcinoma for chronic hepatitis B patients at high risk
Interferon-based treatment is superior to nucleos(t)ide analog in reducing HBV-related hepatocellular carcinoma for chronic hepatitis B patients at high risk
Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
王建昌的其他基金
相似国自然基金
抗SARS病毒的拟肽类蛋白酶抑制剂研究
组织蛋白酶手性拟肽类抑制剂的合成及抑制分子机制揭示
海洋肽类BACE1抑制剂的结构优化与活性研究
小分子非肽类β-分泌酶抑制剂的设计、合成和优化