基于可降解锌合金的无缝线血管吻合技术防止吻合口狭窄的实验研究

Traditional needle stitching small vessels is operating time consuming and technically demanding for stitching,patency of vessels is poor in the long term for the suture penetrating injury to the vessel wall and suture-induced stimulation of intimal hyperplasia of small vascular.Sutureless anastomosis is although simple noninvasive,limited by materials.So,our team Therefore, the research group used medical degradable zinc alloy material designed a micro vascular coupler to avoid the problems of suture needle and other sutureless anastomotic methods, which has advantages of biodegradable, small caliber of anastomotic blood vessel, simple operation and biomechanics safety and so on.We will establish animal model of rabbit vascular anastomosis with the vascular stapler and traditional suture anastomosis as control group.Related methods of detections will be performed to assess the effect and efficiency of coupler . Conduct the experiment in vivo and in vitro cells to explore the mechanism of prevention of anastomotic stenosis by the coupler.So we will establish an ideal medthod of sutureless anastomosis of small vessels.

小血管传统针线缝合吻合法操作费时，对缝合技术要求高，且针线对血管壁的穿透性损伤和缝线残留刺激内膜增生致吻合口中远期畅率欠佳。无线吻合血管虽简便无创，但受材料所限，目前尚无理想方法。为此，课题组用医用可降解锌合金为材料设计了一种微小血管吻合器，避免了针线缝合和其他无线吻合方法的存在的问题，其具有生物可降解，吻合血管口径小，操作简便，生物力学安全等优点。本课题拟采用自主设计的血管吻合器与传统缝线法对照，建立兔血管吻合模型。采用相关的检测方法对锌合金吻合器的吻合效率和吻合效果进行评估。通过动物体内实验和体外细胞实验，对锌合金血管吻合器防止吻合后狭窄的机制进行探讨。从而提出一种较为理想的小血管无缝线吻合方法。

小血管传统针线缝合吻合法操作费时，对缝合技术要求高，且针线对血管壁的穿透性损伤和缝线残留刺激内膜增生致吻合口中远期畅率欠佳。无线吻合血管虽简便无创，但受材料所限，目前尚无理想方法。为此，课题组用医用可降解锌合金为材料设计了一种微小血管吻合器，避免了针线缝合和其他无线吻合方法的存在的问题，其具有生物可降解，吻合血管口径小，操作简便，生物力学安全等优点。本课题拟采用自主设计的血管吻合器与传统缝线法对照，建立兔血管吻合模型。采用相关的检测方法对锌合金吻合器的吻合效率和吻合效果进行评估。通过动物体内实验和体外细胞实验，对锌合金血管吻合器防止吻合后狭窄的机制进行探讨。从而提出一种较为理想的小血管无缝线吻合方法，有潜力应用于临床，微小血管吻合手术成功率将大大提高，一大批病人可免除因吻合口狭窄所致的症状复发及再次甚至多次手术的痛苦。