碳纤维促进的解吸与离子化质谱技术研究及在有机分析中应用

Carbon fiber is a kind of new material of organic fiber materials made by carbonization and activation, which has unique physical and chemical structure and rapid adsorption rate, large capacity, high carbon content, easy regeneration characteristics. Nowadays, Carbon fiber is a new star material catching lots of people attentions. Mass spectrometry has been widely used in the fields of food, environment, human health, medicine, national security, and other related fields. Carbon fiber, which is considered as the most promising functional material in the new century, is of great significance and practical value for mass spectrometry analysis. As the key technology of mass spectrometry, the development of independent and innovative ionization technology is very important. The conductivity the carbon fiber is between metals and non metals, at same time the carbon fiber has excellent compatibility, sample carrying and dispersion ability. Thus, the carbon fiber device can not only be processed and used as sample analysis device, but also can be applied to achieve the function of desorption and ionization in the ion source mass spectrometry. The preliminary results show that the carbon fiber ion source has a good ability of sample dispersion capacity and high desorption and ionization.

碳纤维（Carbon fiber）是有机纤维材料经碳化、活化制成的一种新型材料，具有独特的物理、化学结构和吸附速率快、容量大、含碳量高、再生容易的特点，是受人瞩目的新型材料。质谱技术一直在食品、环境、人类健康、药物、国家安全、和其他与分析测试相关的领域有着广泛的应用。将碳纤维这种被认为是新世纪最有发展前景的功能材料用于质谱分析，开创出新型的质谱分析装置和方法将有重要意义和实际应用价值。离子化技术作为质谱的关键性核心技术，发展自主的、创新性离子化技术至关重要。碳纤维优异的样品兼容性、承载和分散能力和介于金属与非金属之间的导电性，使其不仅可以作为样品采集的装置，也可以被加工成样品分析装置，在质谱离子源中实现解吸和离子化功能。初步研究表明碳纤维离子源有出色的样品分散能力高效的解吸与离子化能力，对有机分析研究将起到积极的推动作用。

本项目的研究围绕完成一些新型质谱离子化方法的探索、开发和应用研究，并发挥质谱技术特长解决有机化学问题。离子化技术是质谱的关键性核心技术，在基于对碳纤维离子化技术充分的理解上，项目组旨在寻求更为方便有效的快速解吸离子化技术。研究中通过总结常压离子化技术的内在规律特点，进一步发展和拓展了常压质谱技术和研究策略，发展出了简便的快速喷雾离子化技术(Fast Eruption Desorption Ionization, FEDI)，并开展了碳纤维探头的场电离(FI，Field Ionization)质谱技术研究。开展了实时直接分析 (DART)离子化对碳硼烷类分子的研究和表征，研究了多硼复杂同位素轮廓峰的归属，并发展了基于高分辨质谱技术对稳定同位素标记率测定和计算方法。还对一些有机化学反应的机理展开了研究，运用质谱学技术和方法才获得了一些确凿的实验证据，为研究有机化学提供独特的信息。