CD4+CD25high调节性T细胞的FOXP3表达异常在不明原因复发性自然流产中的作用研究

Unexplained recurrent spontaneous abortion ( URSA ) is a major concern issues of reproductive health, the incidence is increasing. Some scholars point out, the maternal-fetal immune balance in establishing and maintaining is closely related to the CD4+CD25+Treg immunosuppressive function. Foxp3 is a characteristic sign of CD4+CD25+Treg cell, there is no report about epigenetic features of CD4+CD25highT cells and FOXP3 and the role mechanism in URSA. LIT was firstly applied to the URSA treatment of immunological methods, we has been carried out for many years. Mata analysis indicated that, LIT can be improved about 16.3% live birth rate in URSA. However, so far, LIT therapeutic mechanism has not been fully elucidated, given that the CD4+CD25+Treg in maternal-fetal immune tolerance in the important role of the task group, vision: LIT is possible through effects on CD4+CD25highT cells, FOXP3 expression, thereby improving the maternal-fetal immune tolerance, in favor of normal pregnancy maintenance. To further illustrate some of the maternal-fetal immune tolerance disorders associated with pregnancy complications especially in the occurrence and development of URSA lays the foundation for its diagnosis and treatment.

原因不明性复发性自然流产（URSA）是备受关注的生殖健康问题，发生率日益增加。有学者指出，母胎免疫平衡的建立和维持与CD4+CD25+Treg的免疫抑制功能密切相关。Foxp3是CD4+CD25+Treg细胞的一个特征性标志， CD4+CD25highT细胞和FOXP3表观遗传学特点如何及在URSA中的作用机制，目前尚无相报道。LIT是首先应用于URSA治疗的免疫学方法，我科已开展多年。有Mata分析指出，LIT能将URSA活产率显著提高约16.3%。然而迄今为止，对于LIT治疗机制尚未完全阐明，鉴于CD4+CD25+Treg在母胎免疫耐受中的重要作用，本课题组设想:LIT是否可能通过影响CD4+CD25highT细胞、FOXP3的表达，从而提高母胎的免疫耐受力，有利于正常妊娠的维持。为进一步阐明某些与母胎免疫耐受紊乱相关的妊娠并发症尤其是URSA的发生发展奠定基础，为其诊疗提供。

原因不明性复发性自然流产（URSA）是备受关注的生殖健康问题，发生率日益增加。有学者指出，母胎免疫平衡的建立和维持与CD4+CD25+Treg的免疫抑制功能密切相关。Foxp3是CD4+CD25+Treg细胞的一个特征性标志， CD4+CD25highT细胞和FOXP3表观遗传学特点如何及在URSA中的作用机制，目前尚无相报道。LIT是首先应用于URSA治疗的免疫学方法，我科已开展多年。有Mata分析指出，LIT能将URSA活产率显著提高约16.3%。然而迄今为止，对于LIT治疗机制尚未完全阐明，鉴于CD4+CD25+Treg在母胎免疫耐受中的重要作用，本课题组设想:LIT是否可能通过影响CD4+CD25highT细胞、FOXP3的表达，从而提高母胎的免疫耐受力，有利于正常妊娠的维持。为进一步阐明某些与母胎免疫耐受紊乱相关的妊娠并发症尤其是URSA的发生发展奠定基础，为其诊疗提供。