多发性硬化的遗传研究
基本信息
结项摘要
MS易感性与遗传有关。用单位点和单体分析三个侯选区中位点对MS易感性影响。MS均按公认标准确诊。MS病人和无亲缘关系个体对照，加里福尼亚州高加索人分别为120和107例，中国汉人32和32例。结果：HLAⅡ类DR2同型，DRB*1501-DQA1*0102-DRB1*0602对MS有影响，而染色体18q23上MBP座位无影响。染色体19q13.2区5个座位同型分布：D19S178，D19S574，APOE，APOC2和D19S219，对照和病人间无明显差异。高加索病人中D19S574有明显作用。DR2和染色体19q13.2或MBP间无明显相关。结论：高加索和中国人染色体19q13.2单座位同型与MS密切相关，提示一种邻近易感座位的作用，应研究非HLA座位对MS遗传易感性的影响。
项目摘要
项目成果
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数据更新时间：2023-05-31
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