CGRP促进MSCs迁移在脊髓损伤修复中的作用和机制研究

Spinal cord injury is a severe traumatic disease in central nervous system，and the problem of regeneration and repair has been plaguing experts and scholars in this field. In recent years, Many scholars have tried to repair the spinal cord injury by using mesenchymal stem cells (MSCs) and achieved certain effect. As we all know, the key to the treatment reliies mostly on the homing of transplanted MSCs to the injury site for rebuilding the damaged spinal cord. Our study demonstrated firstly, calcitonin gene-related peptide (CGRP) could dramatically promote the migration and homing of MSCs in the site of injured spinal cord. We also preliminarily verified that the PI3K/Akt and p/ 38-MAKP signaling pathways were involved in the CGRP-induced migration of MSCs. Colletively, the project aims to illustrate the effect and mechanism research of CGRP promoting MSCs migration in the repair of spinal cord injury, and aims to provide an important theoretical basis for clinical treatment on spinal cord injury.

脊髓损伤（SCI）是一种严重的中枢神经系统损伤性疾病，其损伤后的再生和修复问题一直困扰着本领域的专家学者们。许多学者尝试利用间充质干细胞（MSCs）治疗脊髓损伤的修复，取得了一定的效果，但也存在局限。众所周知，治疗脊髓损伤的关键在于移植的MSCs能够归巢至损伤部位来修复和重建损伤的脊髓。本研究首次发现，降钙素基因相关肽（CGRP）可以很好地诱导移植的MSCs在损伤脊髓处的迁移和归巢。此外，我们还初步验证了PI3K/Akt和p/38-MAKP信号通路参与了CGRP对 MSCs迁移的调节过程。而在CGRP的调节下MSCs细胞是如何迁移的？迁移至损伤处的MSCs的分化和轴突再生情况如何？这些也都是亟需我们进一步探索的关键问题。本项目旨在阐明CGRP促进MSCs迁移在脊髓损伤修复中的作用及相关调控机理，为临床上细胞移植治疗脊髓损伤和进一步寻找脊髓损伤的新的治疗靶点提供重要的理论依据。

脊髓损伤（SCI）是一种严重的中枢神经系统损伤性疾病，其损伤后的再生和修复问题一直困扰着本领域的专家学者们。许多学者尝试利用间充质干细胞（MSCs）治疗脊髓损伤的修复，取得了一定的效果，但也存在局限。众所周知，治疗脊髓损伤的关键在于移植的MSCs能够归巢至损伤部位来修复和重建损伤的脊髓。本研究首次发现，降钙素基因相关肽（CGRP）可以很好地诱导移植的MSCs在损伤脊髓处的迁移和归巢。此外，我们还初步验证了PI3K/Akt和p/38-MAKP信号通路参与了CGRP对 MSCs迁移的调节过程。而在CGRP的调节下MSCs细胞是如何迁移的？迁移至损伤处的MSCs的分化和轴突再生情况如何？这些也都是亟需我们进一步探索的关键问题。本项目旨在阐明CGRP促进MSCs迁移在脊髓损伤修复中的作用及相关调控机理，为临床上细胞移植治疗脊髓损伤和进一步寻找脊髓损伤的新的治疗靶点提供重要的理论依据。