蛋白聚糖VGI诱导小鼠脊柱炎的免疫病理学研究
基本信息
结项摘要
体外合成人蛋白聚糖VG1。应用重组人VG1诱导BALB/c小鼠产生人强直性脊柱样改变。观察病鼠大体、病理学和免疫组织化学特点，观察人体不同组织中VG1含量的改变。从AS患者和病鼠T细胞中分离VG1特异性T细胞系/克隆，将AS病变通过上述细胞转移至SCID小鼠，为深入理解AS的免疫发病机制、探讨针对VG1的主要T细胞抗原决定簇治疗AS奠定理论基础。
项目摘要
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数据更新时间：2023-05-31
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