铜硫属化物纳米晶发光探针的近红外局域表面等离子体共振及其在生物医学分析中的应用研究

Preparation of new luminescent materials with high quantum yields in near-infrared region and multi-functions is benefit not only to developing spectral analytical probes, but also to the researches in clean energy and biomedical fields. This research is to develop new luminescent nanocrystals of copper chalcogenide nanocrystals (CuCNCs) with varieties of geometrical shapes such as nanodots, nanowires, nanorods, nanotubes and nanosheets mainly through hydro-thermal synthesis with the purposes of constructing new speedy and sensitive bioanalytical methods, investigate the relationship between the localized surface plasmon resonance (LSPR) and the near-infrared absorption/emission properties around the scientific problem of resolving the newly established near-infrared LSPR of copper chalcogenides nanocrystals, and further apply the luminescent nanocrystals for near-infrared photoelectric sensing, near-infrared imaging, and photothermal therapy. With the aids of chemical synthesis and the newly developed concept of plasmonics in physics, this research can develop lots of new luminescent probes with good emission abilities possibly applied in near-infrared region through characterizing the affecting factors of emission properties such as sizes, shapes, surface charges of the nanocrystals, and the conditions of their surrounding medium, showing high promise since it has both theoretical innovations and applicable potentials, and thus is of benefit not only to the spectral analytical chemistry, but also to the relative research fields such as clean energy and biomedicines.

制备高亮度、近红外和多功能发光纳米材料不仅在光谱分析探针研究、而且在洁净能源和生物医学研究中有广泛应用前景。本项目拟通过水热合成等方法制备小粒径、近红外、光热转换效率高的点、线、棒、管、片、笼等不同形体的铜硫属化物纳米晶(CuCNCs)，以建立快速灵敏的生物分析方法为目标，以解析新近发现该类纳米晶的近红外局域等离子体共振（LSPR）为关键科学问题，研究不同形体CuCNCs的LSPR与其在近红外区光吸收、发射与光热转换关系，并应用到近红外区光电传感、成像分析与光热治疗中。项目结合化学合成和物理表征,探讨颗粒大小、形状、表面电荷、介质条件等因素对CuCNCs发光性能的影响，制备出一系列发光性能及应用前景好的近红外新型光谱探针。项目着眼于CuCNCs的LSPR近红外特性，引用物理学中最新的等离子体学研究成果，既有理论创新，又有实用价值，对光谱分析化学和其他如能源、生物医学的相关研究都有重要意义。

铜硫属纳米材料因其可调的近红外局域表面等离子体共振（LSPR）光学性质在洁净能源、化学和生物医学研究中有广泛应用前景。本项目选择铜硫属纳米晶（copper chalcogenide nanocrystals, CuCNCs）为研究对象，以其近红外区LSPR作为研究主线, 从而开发出了有实际应用前景的新型发光纳米探针并将其应用于生物医学的发光与实时分析中。按照预期计划，项目取得了以下主要进展：. 1.通过改变反应条件合成了一系列不同形貌、组成、在近红外区有特征LSPR特性、吸热效率高的CuCNCs，并对其反应机理进行了详细探讨。. 2.应用合成CuCNCs新型发光纳米探针建立常规的生物医学分析新方法实现对重大疾病的生物标志物或具有重要药用前景的蛋白质、DNA的生物传感。进一步选择肿瘤细胞为监控对象，利用CuCNCs近红外区LSPR和高光热转换效率开展近红外区成像分析和光热治疗研究。. 3.结合化学合成和物理表征探讨了颗粒大小、形状、表面电荷、周边介质等因素对CuCNCs发光性能的影响。在理论上探讨CuCNCs近红外区LSPR与其吸收和散射的关系。