用转基因果蝇研究联想式学习与记忆的分子和细胞基础

Drosophila was used as a model system in eukaryotic genetics throughout the last century and the wealth of its mutants makes it an invaluable tool for neurobiology. Facilitated by genetic manipulation great progresses have been achieved in the studies of Drosophila associative learning through behaviour and molecular analysis of mutanes. The power of it genetics can be applied to study the molecular mechanisms of these human disease gene functions. .Dut to th homology between Drosophila and human diseases genes, it is feasible to study the pathology of human neuronal disorders such as Alzhiemer's and Parkinson's diseases on transgenic Drosophila.. In Drosophila, disease proteins mediated neurotoxicity appears in the corresponding transgenic Drosophila. Alzhiemer's disease transgenic Drosophila model is characterized defined histologicaliy by two distinguishing pathologies: amyloid plaques, which are extracellular deposits consisting mainly of aggregated β-amyloid peptide, and neurofibribrillary tangles, which are intracellular deposits consisting predominantly of hyperphosphorylated tau protein. Based on our existing transgenic Drosophila models, drug screenig system is formed and be used to screen the effective drugs for treating human neurodegenerative diseases...In our approach, we combine forward and reverse mutagenesis with molecular biology, anatomy behavior and pharmacology studies, aiming at the discovery of new genes related to learning /memory and human neurodegenerational diseases.

转基因果蝇的最新研究结果证明，人类APP的表达涉及果蝇的细胞粘连和信号转导途径。它羰疚颐怯米蚬芯垦坝爰且涞姆肿雍拖赴Ｍü胧绞泳酢⑿峋醯男形笛椤⑴嘌窬哪て榧锹肌⑸懊庖咦榛仁侄危教諥PPL缺失果蝇的学习记忆能力南喙厣窬葜剩芴宓鞍椎男藕抛蓟疲辉诨蛩缴咸峁┛煽康睦砺垡谰荨