姜黄素调控HIF-1逆转缺氧诱导肺癌耐药的机理研究
基本信息
结项摘要
姜黄素因高效,低毒,抗癌谱较广被美国国立肿瘤所列为第三代癌化学预防药.姜黄素逆转肿瘤细胞耐药的研究较少,仅限于可抑制MDR-1的基因表达,减低P-gp的产物。姜黄素是否通过调控缺氧诱导因子-1(HIF-1)逆转肺癌耐药的文献,未见报道.我们在前期的研究工作中发现:HIF-1可能是缺氧诱导耐药中一个关键分子,姜黄素可抑制耐药肺癌细胞HIF-1的高表达,推测姜黄素通过HIF－1调控下游耐药相关基因的转
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数据更新时间：2023-05-31
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