听觉老化过程中内质网应激介导细胞凋亡的信号转导及调控机制的研究
基本信息
结项摘要
体外诱导螺旋神经节细胞产生内质网应激反应,分析钙稳态及内质网相关蛋白的表达活化与凋亡的关系,探讨内质网途径凋亡的胞内信号转导机制及其调控机制。在体研究老年性耳聋动物模型，分析内质网凋亡与老年性听功能受损之间的关系。经圆窗膜途径导入腺病毒载体介导的凋亡抑制基因Bcl-2，观察其对阻逆老年性听力减退发展的作用，同时探讨Bcl-2基因对内质网凋亡的调控作用，为临床预防和治疗老年性耳聋提供理论依据及新的线索。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver
IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver
龚树生的其他基金
相似国自然基金
安石榴苷调控内质网应激介导肝细胞脂凋亡的分子机制研究
羊肉成熟中内质网应激介导细胞凋亡的作用机制
内质网应激在间充质干细胞老化过程中的作用及其机制研究
内质网应激通过FoxO1导致胰岛β细胞凋亡的信号转导机制的研究