高稳定性缺陷多级孔MOFs材料的可控制备及生物催化研究

Hierachically porous MOFs are considered to be promising biocatalytic materials in the field of macromolecular separation, catalysis and drug delivery, duo to their unique pore architectures. This project is focus on the synthesis of highly stable and defective hierachically porous MOFs and their biocatalytic properties based on stable microporous MOFs, by “selected acid and base corrosion” method, using the engineering of defect theory. The reaction conditions, assembling laws and host-guest interaction of these materials will be studied and the relationship between assembling routes and the composition, structure, defects and morphology of the materials will be discussed. Thus, the advantage of enzyme supported on hierachically porous MOFs will be also investigated according to their biocatalyst performances. This work can be expected to provide some ideas on how to develop and extend novel and efficient biocatalytic system.

多级孔MOFs材料由于具有独特的孔尺寸分布，在大分子分离、催化、药物控释等领域具有重要的应用，是一种极好的酶催化剂负载材料。本项目以稳定微孔MOFs为前提，采用“酸、碱选择性腐蚀”新策略，利用缺陷工程的原理，实现可控制备高稳定的缺陷位多级孔MOFs材料，通过缺陷多级孔MOFs材料对酶催化剂的固载，探讨复合材料生物催化性能。研究复合材料的合成、组装规律及主-客体相互作用，探讨组装方式与材料的结构、组成、缺陷和形貌的关系；通过生物催化性质的研究，进一步明确高稳定的缺陷位多级孔MOFs材料作为酶催化剂新型载体的优越性，为新型高效生物复合催化体系的构建提供借鉴。

本项目紧紧围绕高稳定性Zr基MOFs材料的设计及合成、缺陷的制造与控制、稀土基MOFs材料的设计及合成、NPs@Por-MOFs复合材料的形貌控制及催化性能研究等四方面展开研究。探索新的拓扑结构及连接方式，实现可控制备高稳定性MOFs及复合MOFs材料。研究复合材料的合成、组装规律及主-客体相互作用，探讨组装方式与材料的结构、组成、缺陷和形貌的关系；通过催化性质的研究，进一步明确高稳定的缺陷位MOFs材料作为催化剂新型载体的优越性，为新型高效复合催化体系的构建提供借鉴。