疏水亲脂作用促进的构象变化及识别作用

In this project, we studied hydrophobic-hydrophilic interaction-driven coiling and aggregation of several new series of synthetic molecules and their complexing behavior to som guests. 1) We synthesized several CTV derivatives incorporating three cholic acdi moieties and investigated their coiling properties in polar solvents. 2) We synthesized four derivatives containg three aromatic moieties and investigated their complexing behavior to fullerene in arenas. 3) We designed and synthesized a new class of bolaamphiphilic molecules and studied their deaggregating ability in aqueous medium. 4) We synthesized four linear molecules which incorporate one electron rich moiety and one electron acceptor moiety and studied their fluorescent behavior in binary solvents.

本课题研究由疏水亲脂作用引起的并人两亲片段的分子构象随溶剂极性的变化, 分子内的簇集和自卷曲。研究疏水亲脂作用促进的分.子识别。设计合成新的结构可变主体分子，在强匀芗林醒芯科溆胫行杂谢肿又涞娜跸嗷プ饔靡约按丶土淳砬苑肿蛹淙跸嗷プ饔玫挠跋?。对于深入了解疏水亲脂作用在生命体系中的作用本质有重要意义。......