如何保护那些容易受到损伤而变性死亡的中脑黑质多巴胺(DA)能神经元一直是帕金森病治疗研究的热点之一。有研究认为,胶质细胞系源性神经营养因子(GDNF)能够通过促进DA能神经元中钙结合蛋白(CB)的表达而保护DA能神经元,但GDNF的这一作用机制尚不明确。本项目研究采用免疫荧光染色结合计算机图像分析、Western blot及Northern blot等方法,研究黑质DA能神经元发育过程中,与GDN
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数据更新时间:2023-05-31
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