CB介导的GDNF对多巴胺能神经元保护作用的分子机制研究

基本信息
批准号:30570564
项目类别:面上项目
资助金额:8.00
负责人:高殿帅
学科分类:
依托单位:徐州医科大学
批准年份:2005
结题年份:2006
起止时间:2006-01-01 - 2006-12-31
项目状态: 已结题
项目参与者:虞正权,张凤真,刘洪梅,袁红花,王梅申,王红军,丁艳霞,王炎强,王婷
关键词:
molecularmechanismGDNFdopaminergicneuronscalbindin
结项摘要

如何保护那些容易受到损伤而变性死亡的中脑黑质多巴胺(DA)能神经元一直是帕金森病治疗研究的热点之一。有研究认为,胶质细胞系源性神经营养因子(GDNF)能够通过促进DA能神经元中钙结合蛋白(CB)的表达而保护DA能神经元,但GDNF的这一作用机制尚不明确。本项目研究采用免疫荧光染色结合计算机图像分析、Western blot及Northern blot等方法,研究黑质DA能神经元发育过程中,与GDN

项目摘要

项目成果
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数据更新时间:2023-05-31

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