水罗伞生药学及其活性成分的研究

Shuiluosan is a crude drug usually used in medical treatment of mental.retardation in children, senile dementia, wind-dampness ostecolnia and fracture etc. in traditional.Yao and Zhuang medicine of Guangxi. The paper is to repot the positive results of.pharmacognostic systematically study about it and its pharmacological action and activated.components in combined the modern science and technology method with the traditional.experience used the drugs in Yao and Zhuang medicine. The original plants and distinctive.characteristic about it and its similar drug has been established through investigation . It was found.that the activated parts from the ethanol extract and dissolved in chloroform of the drug has.pharmacologic action of improve memory, antiinflammation, sedation and antiaging through.filtrate with various model of animal. 6 crystal compounds were isolated from the ethanol extract.dissolves in chloroform through column chromatography. Among them the 4 constituents were.identified as karanjin（Ⅰ）, 3′- methoxykaranjin (Ⅱ) ,pinnatin（Ⅴ）and 5′-methoxyfurano[4.″、5″-8、7]-flavone(Ⅵ) ,and their structures elucidated through physicochemical and spectral.data（UV, IR, MS, 1HNMR, 13CNMR, DFPT, 1H13C cosy or MBC）analysis respectively . The.国家自然科学基金资助项目结题报告.3.compounds were isolated from Fordia cauliflora for the first time. At one time Karanjin also was.obtained from similar drug of Shuilousan. The contents of total flavone, karanjin and 3′-.methoxykaranjin was determined by UV, TLC-S and RP-HPLC in the Shuilousan as well as its similar.drug from differ growing area respectively. The These methods are convenient, sensitive, accurate,.reproducible and can be used the quality control of the drug. It was found that the content of.karanjin from Shuilousan more than its similar drug. 3′- methoxykaranjin not was found from the.similar drug.. 11 Papers are wrote on the investigation. Among they 8 pieces was already published..There are 4 pieces on the key magazine. A quality standard for shuiluosan was drafted.The.scientific evidences for effective and safe property of the drug used clinic, and quality control of.the drug ,with reason using the natural pharmaceutical resources and further developing improving.memory , antiaging and anti-inflammation has be provided. It is important sense for promoting.modernization of national traditional medicine ,developing economy and culture of national area..

水罗伞为壮、瑶医治疗小儿弱智、老年性痴呆症、骨折等症的传统药物。采用壮、瑶医用药经验与现代科技手段相结合对其进行生药学、成分化学及益智抗炎等药理作用的系统研究，探讨其黄酮活性成分及质控检测方法和指标，为水罗伞质量标准的制定和进一步开发益智、抗炎药物资源提供科学依据。这对于弘扬民族医药学、发展民族地区经济文化有重要意义。