抑颤汤治疗帕金森氏病的实验研究

Objective : To explore the mechanism of action in the treatment of Parkinson's disease (PD) with Yichantang. Methods: A PD rat model was made and a normal control group, a normal saline control group and a Yichantang group were set up to observe changes in the rats' behavior pattern and the cerebral black substance cells. Using the technique of intracerebral dialysis, the content of monoamine substances in the ECF was measured by means of HPL and changes in the affinity and quantity of M and DA receptors were measured. Changes in PD patients' symptoms were observed and analyzed and the intensity of DA receptors was measured by PET before and after treatment with Yichantang . Results: Yichantang markedly improved the rats' rotation while enhancing the Bmax and KD of DA and M receptors in the brain tissues on the lesioned side. The levels of DOPAC, HVA, DA and 5-HT in the ECF of caudate nucleus and shell nucleus on the lesioned side were significantly lower than those on the unlesioned side. The treatment resulted in a marked difference from the normal saline group (P< 0.05). Conclusion: Yichantang can increase the affinity and sensitivity of DA and M receptors by stimulating the receptor system of the PD model rats, help the striate body of the black substance on the lesioned side to secret CA substances, and facilitate the repair of the lesioned black substance cells. The results of PET showed that Yichantang can effectually improve the intensity of PD patients' DA receptors.

多年临床观察抑颤汤治疗帕金森病有效，但机理不明。通过PET观察帕金森病患者治疗前后喟桶肥芴寤钚缘母谋浼耙植乐瘟婆两鹕〈笫竽Ｐ秃笠阴５睿グ防啵颍被∷峒捌湎嘤Φ氖芴迨坑肭缀土Φ谋浠芯磕宰橹翁Ш屠野彼狒腔秆粜韵赴母谋洌教忠植赖闹瘟谱饔茫髌淞菩Щ疲幸揭┲瘟婆两鹕√峁┛凸劾砺垡谰荨?...