基于聚苯胺有机光热治疗骨架简捷构筑多功能化抗癌组装体

Photothermal therapy (PTT) is an emerging cancer treatment with outstanding specificity and minimal invasiveness. Photothermal materials play a crucial role in the PTT application, which is one of the hotspot research in chemical, materials, and biological sciences, etc. Herein, to solve the water-soluble and multifunctional issues of organic photothermal nanomaterials, this project attempts to design and synthesize a class of cyclodextrins-modified polyaniline-based organic PTT material with water solubility and several guest molecules with function including targeting, photodynamic therapy, chemotherapy, etc. The functional assembly is concisely constructed via host-guest interaction between cyclodextrin unit of organic PTT material and functional guest molecules, and then PTT-based multifunctional anticancer therapies are explored. By conducting the above work, we will reveal the relationship between host-guest molecular structures and assembly functions, and clarify influence of host-guest interaction on the assembly function, further guiding molecular design and assembly. Moreover，the obtained achievement not only provides a new method for the preparation of multifunctional anticancer platform based organic PTT nanomaterials, but also establishes an experimental and theoretical foundation as well as provides technical support for development of valuable cancer treatment system.

光热治疗（PTT）是一种副作用小、选择性高的新兴癌症治疗方法。而光热材料在PTT应用中起到至关重要的作用，其研究是当今化学、材料和生物等多学科的研究热点之一。本项目针对有机光热纳米材料应用中亟待解决的水溶性和多功能化问题，拟设计合成一类环糊精修饰的水溶性聚苯胺基有机PTT材料与几个具有靶向、光动力学治疗、化疗等功能的客体分子，利用有机PTT材料上环糊精单元与功能客体分子间主客体相互作用简捷构筑多功能组装体，开展基于PTT的多功能抗癌治疗研究。通过以上工作的开展，将阐明主客体分子结构与组装体功能的关系，揭示主客体作用对组装体功能的影响规律，并进一步指导分子设计和组装。另外，该研究成果不仅可以为制备基于有机PTT纳米材料的多功能抗癌平台提供新方法和新途径，还可以为获得具有应用价值的癌症治疗体系奠定理论、实验基础和提供技术支持。

光治疗是一种副作用小、选择性高的新兴癌症治疗方法。而光治疗活性材料在光治疗应用中起到至关重要的作用，其研究是当今化学、材料和生物等多学科的研究热点之一。本项目开展了系列聚苯胺类共轭有机聚合物纳米材料、透明质酸基纳米材料和碳纳米材料的制备、修饰及其多功能化光治疗肿瘤的研究。通过这些工作的开展，发展了一类新型有机共轭聚合物光治疗材料，建立了利用碳量子点金属离子掺杂、表面基团保留等策略制备特定光治疗功能材料的新方法，并极大创新了多功能光治疗材料的制备方法和丰富了多功能光治疗材料种类。为获得具有应用价值的光治疗癌症体系提供了重要的技术支持和理论参考。在项目资助下，已在包括Small、ACS Appl. Mater. Interfaces、Carbon、Chem. Commun.等SCI期刊发表论文11篇和获授权发明专利2个；培养和协助培养硕士研究生5名。