钛/锌协同注入改性碳纤维增强聚醚醚酮促进种植体周围软/硬组织结合的研究

Polyetheretherketone (PEEK) is a tooth coloured material with excellent biomechanical properties, which has the potential to serve as an aesthetic dental implant material. Ideal dental implants should enjoy stable osseointegration, healthy soft-tissue integration and sustained antimicrobial activity. In this work, on the basis of our previous work, carbon fiber reinforced polyetheretherketone (CFRPEEK) with good biocompatibility is preferably applied as the substrate material incorporated with titanium (Ti), zinc (Zn) ions using plasma immersion ion implantation & Deposition technology (PIIID), constructing a unique multilevel nanostructure with enhanced osseointegration, soft-tissue integration and antibacterial effects. The influence of the modified surface on bone mesenchymal stem cells, epithelial cells and multiple microorganisms will be investigated and then the incorporated ratio of Ti/Zn ions will be well optimized for constructing the new CFRPEEK implant. Canines are used for the systematic evaluation of in vivo early osseointegration and soft-tissue integration effects. The constructed CFRPEEK implant takes full advantage of surface chemistry and nano-topography to effectively control both osseo-/soft-tissue integration and microorganisms, which is expected to provide an effective alternative for the oral clinical application.

聚醚醚酮（PEEK）具有良好的力学性能，且因其与天然牙颜色相近，具有作为美学种植修复材料的潜力。理想的牙种植体应具备稳定的骨结合，健康的软组织封闭及适当的抗菌活性。课题组在前期工作基础上，优选具有良好生物相容性的碳纤维增强聚醚醚酮（CFRPEEK）作为基体材料，利用等离子体浸没离子注入与沉积技术（PIIID）在其表面获得含钛（Ti）、锌（Zn）离子的多级微纳结构，综合利用成分及结构潜在的促骨结合、软组织愈合及抗菌效果，在深入探讨Ti/Zn复合离子对骨髓间充质干细胞、牙龈上皮细胞及口腔复合菌群作用机制的基础上，优化离子掺入比例，构建新型CFRPEEK种植体，通过犬拔牙后种植模型，系统评价体内早期软/硬组织结合效果。本课题构建的二元离子注入CFRPEEK将微纳形貌及活性离子的优势有机结合，实现对种植体周围软/硬组织和微生物的有效调控，可望为新型种植体材料的临床应用提供依据。

聚醚醚酮(PEEK)具有良好的力学性能，且因其与天然牙颜色相近，具有作为美学种植修复材料的潜力。理想的牙种植体应具备稳定的骨结合，健康的软组织封闭及适当的抗菌活性。本项目优选具有良好生物相容性的碳纤维增强聚醚醚酮（CFRPEEK）作为基体材料，利用等离子体浸没离子注入与沉积技术（PIIID）在其表面获得含钛（Ti）、锌（Zn）离子的多级微纳结构。钛/锌协同注入可在CFRPEEK表面构建纳米坑状结构和纳米颗粒共存的多级复合结构，此种复合结构可有效促进BMSCs在材料表面的粘附、增殖及成骨分化，同时能够促进牙龈成纤维细胞粘附、增殖。抗菌性评价显示，CFRPEEK构建的复合结构对种植体周围炎相关细菌具有一定的抗菌性能，能够有效抑制细菌增殖和成膜。本项目构建的复合表面有效促进种植体周围软/硬组织和微生物的调控，可望为新型种植体材料的临床应用提供依据。