磁控纳米泡阀与细胞自噬的形变理论研究

The deformation of polymersome nanovalve, such as the closure of the phagophore, is ubiquitous in vivo, and plays a key role in both autophagy and the development of membrane-bound organelles. The theoretical investigation of its mechanism, however, is still absent. Here, we will develop a new field of theoretical biophysics to investigate the deformation of stomatocyte magneto-nanovalve. The resulted theory, then, be expanded to the situation of electro-nanovalve, which is conducive to reveal the mechanism of autophagy. The topic also matches the emerging application in biochemical and medical fields, for example, how can the drug be remotely transported and released at the target?

纳米泡阀形变（或吞噬泡的闭合）在生命体内无处不在，它不但在细胞自噬过程发挥关键作用，在细胞发育的膜被细胞器形成中也不可或缺，但其理论研究严重滞后。我们以胃状细胞为原型，研究磁控纳米泡阀的形变理论，并将其推广到电场情形，有利于揭示细胞自噬的机制，也为生化和医学领域面临的药物靶向输运和释放的远程控制研究提供理论支撑，同时为理论生物物理开辟新的研究方向。

本项目取得的成果是丰硕的。我们导出的形状方程不但具有普适性，也对电场环境下的形变具有指导意义。我们建立了胃状细胞开口的大小与操控磁场强度之间的定量关系，能很好的解释实验数据。我们还深入研究了聚合酶的保真度和胶质瘤的体外3D生长建模，取得了一系列成果，在国际和两岸产生了广泛的影响。先后8人次受邀做学术会议报告，提升了中国学者的国际影响力。