单光子AD脑Aβ显像剂的研究
基本信息
结项摘要
本项目旨在设计合成新的I-123和Tc-99m标记的Aβ显像剂，并研究其在小鼠体内的生物分布性能，利用体外受体放射性配基竞争结合实验测定新合成的Aβ显像剂的生物活性，在获得实验数据的基础上进行Aβ显像剂的构效关系研究，探讨小分子配体与Aβ纤维之间的相互作用机制。本项目在国内率先进行单光子AD脑Aβ显像剂研究，对开发有自主知识产权的Aβ显像剂具有重要理论意义，对无损伤早期诊断AD、评估AD治疗药物的
项目摘要
项目成果
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数据更新时间：2023-05-31
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