Fe-B-P非晶磁性纳米粒子的磁热效应机制及生物降解动力学研究

It is well known that magnetic dielectric materials with crystal structure are widely used as targeted magnetic resonance illness diagnoses agent. But a serious problem during the application is that such materials are difficult to biodegradate in the simulated body fluid. In order to solve this problem, Fe-B-P nanoparticles with amorphous structure will be prepared by aqueous reduction method. Some basic science issues, such as the relationship between magnetocaloric effect and the particle size, the stability of prepared amorphous Fe-B-P nanoparicles, the effects of components and morphology of the particles on the biodegradability, will be investigated systematically and the mechanism will be announced. The properties will be characterized by using field emission scanning electron microscope (FE-SEM), energy dispersive spectroscopy (EDS), vibrating sample magnetometer (VSM), inductively coupled plasma (ICP) and mössbauer spectrum (MS), etc. The proper conditions for preparing the amorphous Fe-B-P nanoparicles with excellent magnetocaloric effect and ideal biodegradability will be explored. Furthermore, the growing mechanism, the magnetic thermal conversion mechanism, and the dynamics process and the mechanism of degradation of Fe-B-P particles will be revealed. This project is expected to provide a fundamental investigation for promoting the Fe-B-P particles in application of targeted magnetic resonance illness diagnoses agent.

针对目前磁共振成像靶向诊疗剂用晶态磁介质材料难以降解的问题，本文拟采用液相化学还原法制备Fe-B-P非晶纳米粒子，并利用XRD、SEM、VSM、ICP以及穆斯堡尔谱等手段，系统研究磁热效应与纳米粒子粒径之间的关系、非晶Fe-B-P纳米粒子的稳定性、非晶Fe-B-P纳米粒子的组分、形貌对生物降解特性的影响等基础科学问题，并揭示其物理本质，探索和发现获得高磁热效应并可生物降解的非晶Fe-B-P纳米粒子的制备条件，阐明非晶Fe-B-P纳米粒子的生长机理、磁热效应机理及在模拟体液中的降解机理，为非晶纳米粒子材料发展成为磁共振成像诊疗剂用磁介质材料奠定基础，为治疗肿瘤技术提供一条新的技术解决途径。

源于目前磁共振成像靶向诊疗剂用晶态磁介质材料难以降解的问题。利用液相化学还原法制备Fe-B-P非晶粒子，围绕非晶粒子磁热效应与制备条件之间的关系、非晶粒子的稳定性、非晶粒子的组分和形貌对降解特性的影响等基础科学问题，并且探讨和发现获得高磁热效应的非晶粒子的制备条件。通过XRD、SEM、VSM、ICP以及穆斯堡尔谱等手段，本项目找出了制备条件与样品微观结构、超精细结构与软磁性能之间的联系，找出了样品粒径分布、组分、物性与磁热效应之间的关系，用EET理论对非晶粒子的价电子结构进行研究，研究了样品在模拟体液中降解的问题，还对球磨前后非晶粒子的电磁波吸收特性进行了研究。已发表或录用论文6篇，培养了本科生6名，硕士研究生2名。