光引发聚合诱导自组装制备仿生多酚聚合物胶囊及原位功能化

Biomimetic polyphenol polymer capsules have been used in many fields because of their nontoxicity, good biocompatibility and biodegradability. However, their applications have been limited by the template preparation technique and multi-step functionalization. In this project, enlightened by polymerization-induced self-assembly (PISA), a novel method, photo-PISA is proposed to prepare biomimetic polyphenol polymer capsules by using biomimetic polyphenol as photo-initiator based on their π-π stacking. Effects of polymerization conditions on the polymer morphology and polymerization mechanism will be investigated in detail. The proposal will be validated by experiments. Based on properties of PISA, in situ encapsulation of active species into capsules will be studied. The model drug encapsulated in polymer capsules will be prepared and their slow and controlled release properties can be obtained. Gold nanoparticles will also encapsulated into polymer capsule and carbonized. The resultant carbon encapsulated gold bearing yolk structure will act as a catalyst to reduce model reaction. This project will offer theoretical and practical support on preparation and in situ functionalization of biomimetic polyphenol polymer capsules by photo-PISA.

仿生多酚聚合物胶囊作为一种新型胶囊，由于无毒、生物相容性好、可降解等优点而具有巨大的应用前景，然而制备方法(模板法)单一，功能化该类胶囊步骤繁琐局限了其在更多领域的应用。本项目基于前期对该类聚合在光照条件下聚合机理和特点的研究，利用多酚类化合物之间π-π堆积等非共价作用，受聚合诱导自组装技术启发，提出基于多酚小分子光引发聚合诱导自组装制备多酚聚合物胶囊的假设。通过聚合条件及机理的研究，验证该种假设并揭示聚合条件对其形貌的影响规律；通过原位包覆模型药物并研究其缓控释性能，建立原位制备该缓控释体系的新方法并揭示 “构-性”关系；利用该类聚合物易碳化的特点，原位将贵金属（金或银）包覆于胶囊后碳化形成具有蛋黄结构的催化体系并研究其催化性能，为该类聚合物胶囊体系拓展应用范围。通过以上研究，构建一种绿色易行且可原位功能化的仿生多酚聚合物胶囊及衍生物的制备方法，为其宏量制备和应用提供理论依据和技术保障。

摘要：仿生多酚聚合物胶囊作为一种新型胶囊，由于无毒、生物相容性好、可降解等优点而具有巨大的应用前景，然而制备方法(模板法)单一，功能化该类胶囊步骤繁琐局限了其在更多领域的应用。本项目基于前期对该类聚合物在聚合条件及机理的研究，从分子设计的角度，提出基于多酚化合物的聚合诱导自组装制备多酚聚合物胶囊的假设。通过聚合条件及机理的研究，验证该种假设并揭示聚合条件对其形貌的影响规律；通过一步自组装法制备了不同壁厚的聚多巴胺胶囊，系统研究了该胶囊的自组装机理及过程。通过多酚聚合竞争性组装，得到由球到棒的一系列组装体，为设计合成不同的载体材料提供了新的方案。采用原位自组装制备了烷基-聚多酚Janus纳米片，研究了二维Janus纳米片用作乳剂的稳定剂的性能。通过多酚和金属离子的机械力络合聚合，构建了机械力化学成膜载药体系。搭建了适用于喷涂工艺的包膜中试设备，研究了多酚包膜材料的生产工艺。通过以上研究，构建一种绿色易行且可原位功能化的仿生多酚聚合物胶囊及衍生物的制备方法，搭建了完善的包膜工艺，为其宏量制备和应用提供理论依据和技术保障。