MsPGN系膜细胞IL-6mRNA含量与尿IL-6活性的相关研究
基本信息
结项摘要
MsPGN系膜细胞IL-6mRNA含量与尿IL-6活性的相关研究，结果首次证实人胎肾系膜细胞能自分泌IL-6并表达IL-6mRNA，重组TNFα对人胎肾系膜细胞产生IL-6有上调作用，重组IL-2则有下调作用。重组IL-2对IL-6mRNA表达有抑制作用，重组TNFα则有促进作用。证实重组IL-6可促进人胎肾系膜细胞增殖。30例MsPGN尿IL-6活性增高率为60%，非MsPGN为23.3%。尿IL-6活性增高与系膜细胞增殖程度有关，病理改变越重，尿IL-6活性增高越明显。临床表现为肾病综合征的MsPGN尿IL-6活性增高率达91.67%，经RT/PCR证实MsPGN尿IL-6活性增高是与其肾脏本身病理改变所致IL-6mRNA表达增强密切相关。以上提示MsPGN尿IL-6活性测定可作为疾病病情、治疗及预后判断的监测指标。
项目摘要
项目成果
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数据更新时间：2023-05-31
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