GSK3a/b促神经元凋亡作用及信号转导
基本信息
结项摘要
发现GSK-3a/b均为PKA的天然底物，并阐明cAMP/PKA通过磷酸化GSK-3b发挥其抗神经蛲鲎饔茫曳⑾諧REB的转录活性介导了CAMP/PKA的抗凋亡作用；GSK-3b可抑制其转录活浴Ｎ耍颐翘岢觯篏SK-3b是否通过直接磷酸化CREB的Ser129位而发挥促凋亡作用？GSK-3a是否具有相似作用？本研究将为确立GSK-3a/b作为神经退行性疾病的治疗靶位提供充分的蒲б谰荨
项目摘要
项目成果
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数据更新时间：2023-05-31
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