炎症过敏反应的基因治疗

Transcription Factor NF-кB controls a common pathway of transcriptional activation of inducible genes, which can lead to inflammation and tissue injury. So the study regarded Transcription Factor NF-кB as the target of gene therapy. An inflammation inducible vector was firstly constructed, which can response to pathological signals. Then aimed genes could be expressed automatically, according to the changing levels of inflammation reaction. Therefore, an inflammation inducible gene therapy, with autocontrol which could meet clinical needs, have been explored.

转录因子NFkB是机体内介导组织细胞炎症损伤的可诱导基因转录激活的一个共同通道，本研究选择此为基因治疗调控靶向。力图构建炎症诱导性载体，利用能对病理信号响应的启动子，可使目的基因的表达随疾病的病理生量信号改变而改变，受炎性反应水平自动控制，达到动态治疗的目的。我们希企能探索出符合临床实际的具有自控性的抗炎基因治疗新策略。