数学模型法研究体内稀土物种及稀土代谢行为

Biological effects of rare earths are controlled by their speciation. The speciation of rare earths in human interstitial fluid and blood plasma were studied , many interesting results were obtained for the first time.A multi-phase model of rare earths in human interstitial fluid were developed, the multi-model can be used to study speciation of rare earths . Many binary and ternary systems of rare earths with biological molecules in human interstitial fluid were studied systematically, and a lot of accurate stability constants for the complexes in these systems were obtained. Speciation of Pr(lll) in human interstitial fluid were studied by computer simulation, the results obtained are in good agreement with the experimental results. The studied results on speciation of rare earths in human blood plasma can explain the metabolism behavior of rare earths in human body successfully. Rare earths can affect speciation of Zn(ll) and Ca(ll) ions,which may be related to the biological effects of rare earths.

本项目在更深层次上研究体内稀土物种及其代谢行为、生物效应，这不仅可拓宽稀土生物无机化学研究领域，而且对阐明稀土农用作用机理和科学评价其使用安全性具有重大开拓性意义。建立多相形态模型；研究唾液、胃液、肠液、尿、细胞间液和细胞内液中稀土物种，考察稀土代谢行为；研究稀土对生物分子形态影响；研究稀土与生命金属物种间相互影响