HER2/neu 原癌基因及其片段DNA 疫苗抗瘤效应的研究
基本信息
结项摘要
本项目在已验证HER2/neuP185蛋白免疫原性的基础上,通过基因工程技术克隆并构建HER2/neu(cerbB-2)原癌基因及其片段的表达载体,将质粒DNA直接免疫小鼠,利用内源性MHC抗原呈递系统,寻找有效抗瘤效应的亚优势抗原表位,打破机体对P185蛋白的耐受状态,通过主动免疫盏?有限而特异的抗瘤免疫应答,为肿瘤DNA疫苗的研究及应用提供实验基础和科学依据。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
An improved extraction method reveals varied DNA content in different parts of the shells of Pacific oysters
An improved extraction method reveals varied DNA content in different parts of the shells of Pacific oysters
DNA storage: research landscape and future prospects
DNA storage: research landscape and future prospects
The effectiveness and safety of traditional Chinese herbal medicine for the treatment of male infertility associated with sperm DNA fragmentation
The effectiveness and safety of traditional Chinese herbal medicine for the treatment of male infertility associated with sperm DNA fragmentation
KLF14/miR‐1283/TFAP2C axis inhibits HER2‐positive breast cancer progression via declining tumor cell proliferation
KLF14/miR‐1283/TFAP2C axis inhibits HER2‐positive breast cancer progression via declining tumor cell proliferation
Modeling the relationship of diverse genomic signatures to gene expression levels with the regulation of long-range enhancer-promoter interactions
Modeling the relationship of diverse genomic signatures to gene expression levels with the regulation of long-range enhancer-promoter interactions
秦慧莲的其他基金
相似国自然基金
HER2／NEU瘤苗主动免疫诱导特异抗瘤效应的研究
抗体导向的新型HER2/neu肿瘤疫苗研究
HER2/neu受体酪氨酸激酶选择性抑制剂及其抗瘤作用研究
携带Her2/neu的红细胞作为抗乳腺癌疫苗的作用和免疫机制