两种药效相近藏药材-帕里龙胆和大花绿绒蒿的化学成分分析及活性筛选

Chemical component analysis will be carried out for two tibetan medicinal herbs-Gentiana pharica Burk and Meconopsis grandis Prain, which has equal effect to cure hepatitis and lung disease. The chemical compounds molecular structure of two medicinal herbs will be elucidated by mass spectrum,NMR spectum IR spectum,and so on. The chemical compounds' difference and simirality between two herbs will be revealed. The bioactive compounds or drug lead compounds will be found when the model of anti-microbes , anti-hepatitis and cured lung disease are tested for the compounds isolated from two herbs.

选取具有治疗肝病肺病药效相近的常用藏药帕里龙胆和大花绿绒蒿进行化学成分分析，采用现代波谱分析手段，解析其化学成分中单体化合物的结构，揭示两种药材化学成分的异同；并对其化学成分单体化合物进行抗菌、抗肝病、抗肺病等活性筛选，寻找活性化合物和新的药物先导化合物。

项目分别对帕里龙胆和大花绿绒蒿进行了成分分析，并研究了濒危药材大花绿绒蒿的内生真菌的次级代谢产物。发现帕里龙胆提取物有保护肝脏的作用。而从大花绿绒蒿的内生真菌次级代谢产物中发现了抗肿瘤和抗肺结核的成分。项目发表了6篇论文，其中2篇为SCI收录期刊论文。项目申请了3项发明专利。