刺激频率耳声发射对听觉功能频率选择特性的客观检测研究

The objective of this project is to study whether stimulus-frequency otoacoustic emissions suppression tuning curves (SFOAE STCs) could become an accurate, objective and efficient detection method of the human ear's frequency selectivity (FS), so as to replace current psychophysical tuning curves (PTCs) method which needs subjective participation. The characteristics of SFOAE STCs and PTCs, and their relationships are studied at different thresholds for the human's normal hearing ears. Meanwhile, the characteristics and relationships of SFOAE STCs and compound action potential tuning curves (CAP TCs) are also be studied on normal hearing guinea pig ears. From results, the potential of SFOAE STCs being an objective method on FS evaluation of auditory system could be proved. In addition, with human ear's SFOAE STCs and the relationships between mammal's SFOAE STCs and CAP TCs, the human auditory nerve CAP TCs could be speculated and then the frequency selectivity of human auditory system could be obtained. SFOAE STCs could be proved to play a bridge role between behavior measurements and neural responses.The basic theoretical research in this project will lay a solid foundation for SFOAE STCs becoming an accurate, objective and efficient method of clinical evaluation on auditory system frequency selectivity.

为了研究刺激频率耳声发射抑制调谐曲线（SFOAE STCs）能否成为一种准确、客观、高效地对人耳的频率选择特性（FS）进行检测评价的方法，以替代人主观参与的心理物理调谐曲线（PTCs）的方法。本项目研究在不同阈值准则下，听力正常人耳的SFOAE STCs与PTCs的特性和相互关系，以及听力正常豚鼠耳的SFOAE STCs与复合神经动作电位调谐曲线(CAP TCs)的特性和相互关系。证明SFOAE STCs对听觉系统FS进行客观评测的潜力；另外，通过人耳的SFOAE STCs、哺乳动物的SFOAE STCs与CAP TCs之间的相互关系推测出人耳听神经的CAP TCs，从而获得人耳听觉神经系统的频率选择特性，证明SFOAE STCs在联系行为学特征和神经响应之间相互关系的作用。本项目的基础理论研究为SFOAE STCs成为准确、客观、高效的临床评测方法奠定了应用的基础。

频率选择特性（FS）是指听觉系统从一系列频率中分辨出某一频率的能力，是对复杂声音感知的必要属性。目前常用行为学方法来检测人耳FS，如心理物理调谐曲线（PTC），但由于其主观性，需要受试者反馈是否听到刺激声，因此不能应用于难以配合的测试群体（如婴幼儿）。此外，复合神经动作电位调谐曲线（CAP TC）也是用来评估FS的手段，但由于其有创性和复杂性，不适合应用于人体。本项目提出刺激频率耳声发射（SFOAE STC）有具有检测人耳FS的潜力。因此本项目设计了人耳与动物FS测试平台，并研究了不同阈值准则下，听力正常人耳的SFOAE STCs与PTCs的特性及相互关系，以及听力正常豚鼠耳的SFOAE STCs与CAP TCs的特性和相互关系，证明了SFOAE STC对听觉系统FS进行客观评测的潜力；另外，也通过人耳的SFOAE STCs、哺乳动物SFOAE STCs与CAP TCs之间的相互关系推测出了人耳听神经CAP TCs，从而获得了人耳听觉神经系统的频率选择特性，证明了SFOAE STC在联系行为学特征和神经响应之间相互关系的作用，为SFOAE STC成为准确、高效、客观的临床评测方法奠定了应用的基础。